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Lengyel, Ernst Robert

One or more keywords matched the following properties of Lengyel, Ernst Robert

Property	Value
overview	I trained both as a scientist and as a physician and, throughout my career, I have focused on the treatment and biology of ovarian cancer (OvCa). My Ph.D. thesis was on the role of proteases in ovarian cancer and my clinical fellowship involved a special emphasis on the treatment of patients with this disease. As a surgeon and clinician, I am familiar with the presentation of ovarian cancer in patients, and experience the incredible obstacles we face in its treatment. In the laboratory, I have built the research infrastructure necessary for effective ovarian cancer research. The Lengyel lab has elucidated, at least in part, the first critical steps of ovarian cancer metastasis by paying close attention to the host microenvironment. We have collected the 25 most commonly used ovarian cancer cell lines from all over the world, including those which are chemotherapy resistant. We have established several mouse models for OvCa, and using a genetic mouse model (K-rasG12D/+/Pten-/- -- established by Dr. Tyler Jacks), a syngeneic orthotopic mouse model using mouse OvCa cells (ID8 -- established by K. Roby), and several xenograft ip models using primary and cultured human OvCa cells. I have also established a prospective OvCa tissue bank and, together with 2 gynecologic pathologists, we have assembled 13 tissue arrays including normal tissue, borderline tumor and primary tumor, & corresponding metastasis. As a surgeon, the main focus of my practice is patients with OvCa; therefore, I will be able to enroll a substantial number of patients on the proposed clinical trial and have the infrastructure in place to collect the tissue required for the translational studies. My clinical experience treating ovarian cancer, together with my laboratory, which focuses on OvCa biology, gives me a unique opportunity and obligation to find new treatments that can benefit patients with ovarian cancer.

Property

Value

overview

I trained both as a scientist and as a physician and, throughout my career, I have focused on the treatment and biology of ovarian cancer (OvCa). My Ph.D. thesis was on the role of proteases in ovarian cancer and my clinical fellowship involved a special emphasis on the treatment of patients with this disease. As a surgeon and clinician, I am familiar with the presentation of ovarian cancer in patients, and experience the incredible obstacles we face in its treatment. In the laboratory, I have built the research infrastructure necessary for effective ovarian cancer research. The Lengyel lab has elucidated, at least in part, the first critical steps of ovarian cancer metastasis by paying close attention to the host microenvironment. We have collected the 25 most commonly used ovarian cancer cell lines from all over the world, including those which are chemotherapy resistant. We have established several mouse models for OvCa, and using a genetic mouse model (K-rasG12D/+/Pten-/- -- established by Dr. Tyler Jacks), a syngeneic orthotopic mouse model using mouse OvCa cells (ID8 -- established by K. Roby), and several xenograft ip models using primary and cultured human OvCa cells. I have also established a prospective OvCa tissue bank and, together with 2 gynecologic pathologists, we have assembled 13 tissue arrays including normal tissue, borderline tumor and primary tumor, & corresponding metastasis. As a surgeon, the main focus of my practice is patients with OvCa; therefore, I will be able to enroll a substantial number of patients on the proposed clinical trial and have the infrastructure in place to collect the tissue required for the translational studies. My clinical experience treating ovarian cancer, together with my laboratory, which focuses on OvCa biology, gives me a unique opportunity and obligation to find new treatments that can benefit patients with ovarian cancer.

One or more keywords matched the following items that are connected to Lengyel, Ernst Robert

Item Type	Name
Concept	Blood Pressure
Concept	Aging
Concept	Amino Acid Sequence
Concept	Allosteric Regulation
Concept	Cell Communication
Concept	Base Sequence
Concept	Cell Differentiation
Concept	Cell Movement
Concept	Binding Sites
Concept	Cell Division
Concept	Cell Adhesion
Concept	Cell Cycle
Concept	Chemotaxis
Concept	Chicago
Concept	Codon
Concept	Gastrointestinal Neoplasms
Concept	Genital Neoplasms, Female
Concept	DNA-Binding Proteins
Concept	Drug Synergism
Concept	Cytotoxicity, Immunologic
Concept	Chemotaxis, Leukocyte
Concept	Electrophoresis, Polyacrylamide Gel
Concept	Glycerol
Concept	Drug Interactions
Concept	Endocytosis
Concept	Enzyme Activation
Concept	Gene Expression Regulation
Concept	Genes, Dominant
Concept	Glioma
Concept	Guanosine Triphosphate
Concept	Obesity
Concept	Genetic Engineering
Concept	Gonadotropins
Concept	Health Planning Guidelines
Concept	Dose-Response Relationship, Drug
Concept	Hungary
Concept	Energy Metabolism
Concept	Enzyme Induction
Concept	Membrane Glycoproteins
Concept	Gonadotropin-Releasing Hormone
Concept	Microfilament Proteins
Concept	Pregnancy
Concept	Immunocompetence
Concept	Molecular Sequence Data
Concept	Molecular Weight
Concept	Glycogen
Concept	Glycolysis
Concept	Mutation
Concept	Stimulation, Chemical
Concept	Phosphorylation
Concept	Plasminogen Activators
Concept	Protein Precursors
Concept	Protein-Tyrosine Kinases
Concept	Protein Binding
Concept	Proto-Oncogene Proteins
Concept	Pseudogenes
Concept	Proteins
Concept	Gastrins
Concept	Repressor Proteins
Concept	Protein Kinases
Concept	Sequence Homology, Nucleic Acid
Concept	Genes, ras
Concept	Regulatory Sequences, Nucleic Acid
Concept	RNA Splicing
Concept	Solubility
Concept	RNA Processing, Post-Transcriptional
Concept	Sensitivity and Specificity
Concept	Time Factors
Concept	Transcription, Genetic
Concept	Protein Biosynthesis
Concept	Proto-Oncogene Proteins pp60(c-src)
Concept	Hepatocyte Growth Factor
Concept	Sequence Homology, Amino Acid
Concept	Plasminogen Activator Inhibitor 1
Concept	Ultraviolet Rays
Concept	Urokinase-Type Plasminogen Activator
Concept	Phosphotransferases (Alcohol Group Acceptor)
Concept	Germ-Line Mutation
Concept	Geriatric Assessment
Concept	Oncogene Proteins
Concept	Trans-Activators
Concept	Drug Resistance, Neoplasm
Concept	Guanine Nucleotide Exchange Factors
Concept	rho GTP-Binding Proteins
Concept	rac1 GTP-Binding Protein
Concept	Mitogen-Activated Protein Kinases
Concept	Transforming Growth Factor beta
Concept	Extracellular Matrix Proteins
Concept	Genes, BRCA2
Concept	HMGA2 Protein
Concept	Up-Regulation
Concept	Genes, Tumor Suppressor
Concept	Mutagenesis
Concept	Genes, jun
Concept	Proto-Oncogene Proteins c-fos
Concept	Gene Expression
Concept	Proto-Oncogene Proteins c-myc
Concept	RNA Interference
Concept	Protein Structure, Tertiary
Concept	Postmenopause
Concept	Methylation
Concept	Genes, Reporter
Concept	Genomic Instability
Concept	RNA-Binding Proteins
Concept	Immediate-Early Proteins
Concept	Gelatinases
Concept	Apoptosis
Concept	Sequence Deletion
Concept	Cell Proliferation
Concept	Vesicular Monoamine Transport Proteins
Concept	Oxidative Stress
Concept	ras Proteins
Concept	BRCA1 Protein
Concept	Fas Ligand Protein
Concept	Receptor Protein-Tyrosine Kinases
Concept	Protein Transport
Concept	Multidrug Resistance-Associated Proteins
Concept	Protein Tyrosine Phosphatases
Concept	Pentose Phosphate Pathway
Concept	Metabolome
Concept	Vascular Endothelial Growth Factor Receptor-2
Concept	Mitogen-Activated Protein Kinase 8
Concept	Green Fluorescent Proteins
Concept	Vascular Endothelial Growth Factors
Concept	Mitogen-Activated Protein Kinase 3
Concept	Sex Cord-Gonadal Stromal Tumors
Concept	Paracrine Communication
Concept	Proto-Oncogene Proteins c-raf
Concept	Cell Growth Processes
Concept	Cell Cycle Proteins
Concept	Proto-Oncogene Proteins c-kit
Concept	rac GTP-Binding Proteins
Concept	Receptor, Platelet-Derived Growth Factor alpha
Concept	Mitogen-Activated Protein Kinase Kinases
Concept	Genes, BRCA1
Concept	Gene Expression Profiling
Concept	BRCA2 Protein
Concept	Wnt Proteins
Concept	Polyethylene Glycols
Concept	Animals, Genetically Modified
Concept	Gestational Trophoblastic Disease
Concept	Promoter Regions, Genetic
Concept	Focal Adhesion Protein-Tyrosine Kinases
Concept	Receptors, Glucocorticoid
Concept	Recombinant Proteins
Concept	Transforming Growth Factor beta1
Concept	Transforming Growth Factor beta2
Concept	Protein Phosphatase 1
Concept	Suppression, Genetic
Concept	Receptors, Vascular Endothelial Growth Factor
Concept	Fatty Acid-Binding Proteins
Concept	Proteolysis
Concept	Substrate Specificity
Concept	Down-Regulation
Concept	Proto-Oncogene Proteins c-jun
Concept	Cell Death
Concept	Transfection
Concept	Platelet Activation
Concept	Cell Hypoxia
Concept	Genome, Human
Concept	Gene Expression Regulation, Enzymologic
Concept	Retinoblastoma Protein
Concept	Fibroblast Growth Factor 1
Concept	Proto-Oncogene Proteins p21(ras)
Concept	DNA Methylation
Concept	Metabolic Networks and Pathways
Concept	Proto-Oncogene Proteins c-met
Concept	Mitogen-Activated Protein Kinase 1
Concept	Calcium-Calmodulin-Dependent Protein Kinases
Concept	Receptor Cross-Talk
Concept	Anoikis
Concept	Gene Knockdown Techniques
Concept	Homeodomain Proteins
Concept	Genes, erbB-2
Concept	Cell Lineage
Concept	Gadolinium DTPA
Concept	Inhibitory Concentration 50
Concept	MAP Kinase Signaling System
Concept	JNK Mitogen-Activated Protein Kinases
Concept	Vesicular Biogenic Amine Transport Proteins
Concept	Cell Cycle Checkpoints
Concept	Transcriptome
Concept	Tumor Microenvironment
Concept	Vascular Endothelial Growth Factor A
Concept	Homologous Recombination
Concept	Cell Shape
Concept	Lipid Metabolism
Concept	Receptors, Urokinase Plasminogen Activator
Concept	Wnt Signaling Pathway
Concept	Neoplasm Grading
Concept	Carrier Proteins
Concept	Cell Survival
Concept	Chromatin
Concept	Genetic Testing
Concept	Glucose
Concept	Guanosine Diphosphate
Concept	Luminescent Proteins
Concept	Neoplasm Proteins
Concept	Neoplasms, Glandular and Epithelial
Concept	Nuclear Proteins
Concept	Embryo Implantation
Concept	Phenotype
Concept	Phylogeny
Concept	Platelet Membrane Glycoproteins
Concept	Surface Properties
Concept	Translocation, Genetic
Concept	Signal Transduction
Concept	Transcriptional Activation
Concept	Gene Expression Regulation, Neoplastic
Concept	Tumor Suppressor Protein p53
Concept	Genes, Neurofibromatosis 1
Concept	Oncogene Proteins v-fos
Concept	Gonadoblastoma
Concept	Genetic Predisposition to Disease
Concept	Protein Isoforms
Concept	Polymorphism, Single Nucleotide
Concept	Receptor, Platelet-Derived Growth Factor beta
Concept	Genomics
Concept	Membrane Transport Proteins
Concept	Protein Array Analysis
Concept	Eosinophil Cationic Protein
Concept	Protein Kinase Inhibitors
Concept	p38 Mitogen-Activated Protein Kinases
Concept	Proto-Oncogene Proteins c-akt
Academic Article	Regulation of urokinase-type plasminogen activator expression by an ERK1-dependent signaling pathway in a squamous cell carcinoma cell line.
Academic Article	Requirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene.
Academic Article	In vitro modulation of human melanoma cell invasion and proliferation by all-trans-retinoic acid.
Academic Article	Elevated keratin 18 protein expression indicates a favorable prognosis in patients with breast cancer.
Academic Article	Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor.
Academic Article	Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade.
Academic Article	Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades.
Academic Article	[The clinical importance of keratin 18 in breast cancer].
Academic Article	beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter.
Academic Article	Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells.
Academic Article	Gastrin induces expression and promoter activity of the vesicular monoamine transporter subtype 2.
Academic Article	UVB increases urokinase-type plasminogen activator receptor (uPAR) expression.
Academic Article	JNK and p38MAPK are activated during graft reperfusion and not during cold storage in rat liver transplantation.
Academic Article	Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b.
Academic Article	Downregulation of a mitogen-activated protein kinase signaling pathway in the placentas of women with preeclampsia.
Academic Article	Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer.
Academic Article	Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers.
Academic Article	Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor.
Academic Article	Ras regulation of urokinase-type plasminogen activator.
Academic Article	Expression of latent matrix metalloproteinase 9 (MMP-9) predicts survival in advanced ovarian cancer.
Academic Article	Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation.
Academic Article	Isolation and characterization of Rac1 pseudogenes (psi1Rac1-psi4Rac1) in the human genome.
Academic Article	PDGFR-alpha as a potential therapeutic target in uterine sarcomas.
Academic Article	Single-agent pulse dactinomycin has only modest activity for methotrexate-resistant gestational trophoblastic neoplasia.
Academic Article	Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2.
Academic Article	C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu.
Academic Article	Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer.
Academic Article	Does equal treatment yield equal outcomes? The impact of race on survival in epithelial ovarian cancer.
Academic Article	Reversible posterior leukoencephalopathy syndrome following intravenous paclitaxel and intraperitoneal cisplatin chemotherapy for fallopian tube cancer.
Academic Article	Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface.
Academic Article	The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.
Academic Article	An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis.
Academic Article	MMP-2 functions as an early response protein in ovarian cancer metastasis.
Academic Article	Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected colorectal cancers.
Academic Article	Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice.
Academic Article	CD95 promotes tumour growth.
Academic Article	c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion.
Academic Article	A phase II, single-arm study of the anti-a5ß1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer.
Academic Article	Let-7 expression defines two differentiation stages of cancer.
Academic Article	RFLP Molecular Analysis of the Urokinase-Type Plasminogen Activator Gene.
Academic Article	Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1.
Academic Article	Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target.
Academic Article	Ligand-independent activation of c-Met by fibronectin and a(5)ß(1)-integrin regulates ovarian cancer invasion and metastasis.
Academic Article	Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.
Academic Article	The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions.
Academic Article	FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas.
Academic Article	A special key for unlocking the door to targeted therapies of breast cancer.
Academic Article	The effects of 17ß-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis.
Academic Article	Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Academic Article	Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis.
Academic Article	Acute inflammatory reaction following placement of sodium hyaluronate-carboxymethylcellulose barrier in a young woman undergoing gynecologic surgery: a case report.
Academic Article	Rethinking ovarian cancer: recommendations for improving outcomes.
Academic Article	Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure.
Academic Article	Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras.
Academic Article	Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene.
Academic Article	Tyrosine kinase mutations in human cancer.
Academic Article	Keratin expression reveals mosaic differentiation in vaginal epithelium.
Academic Article	The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.
Academic Article	Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors.
Academic Article	The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer.
Academic Article	Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.
Academic Article	The expression of hepatocyte growth factor (HGF) and c-Met in uterine serous carcinoma.
Academic Article	HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts.
Academic Article	Transient interaction of activated platelets with endothelial cells induces expression of monocyte-chemoattractant protein-1 via a p38 mitogen-activated protein kinase mediated pathway. Implications for atherogenesis.
Academic Article	Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue.
Academic Article	A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings.
Academic Article	Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation.
Academic Article	Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation.
Academic Article	Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.
Academic Article	miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin a5 expression.
Academic Article	Serial sectioning of the fallopian tube allows for improved identification of primary fallopian tube carcinoma.
Academic Article	MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer.
Academic Article	Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion.
Academic Article	Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype.
Academic Article	Utility of routine surveillance methods in detecting recurrence in high grade endometrial cancer patients.
Academic Article	Three-dimensional modeling of ovarian cancer.
Academic Article	Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy.
Academic Article	Epithelial ovarian cancer experimental models.
Academic Article	WNT7A/ß-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.
Academic Article	Summary of the 2013 American Association for Cancer Research (AACR) Annual Meeting.
Academic Article	Old drug, new trick: repurposing metformin for gynecologic cancers?
Academic Article	Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models.
Academic Article	Whole-genome characterization of chemoresistant ovarian cancer.
Academic Article	Patterns and utility of routine surveillance in high grade endometrial cancer.
Academic Article	The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma.
Academic Article	Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma.
Academic Article	Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.
Academic Article	Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.
Academic Article	MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment.
Academic Article	Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis.
Academic Article	Corrigendum: Whole-genome characterization of chemoresistant ovarian cancer.
Academic Article	Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity.
Academic Article	A prospective study evaluating diffusion weighted magnetic resonance imaging (DW-MRI) in the detection of peritoneal carcinomatosis in suspected gynecologic malignancies.
Academic Article	Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Academic Article	Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.
Academic Article	Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells.
Academic Article	Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform.
Academic Article	Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube.
Academic Article	Gastrin Induces Expression and Promoter Activity of the Vesicular Monoamine Transporter Subtype 2.
Academic Article	Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity.
Academic Article	Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention.
Academic Article	A High-Throughput Screening Model of the Tumor Microenvironment for Ovarian Cancer Cell Growth.
Academic Article	High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer.
Academic Article	Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer.
Academic Article	Induction of Neoantigen-Specific Cytotoxic T Cells and Construction of T-cell Receptor-Engineered T Cells for Ovarian Cancer.
Academic Article	A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.
Academic Article	Who are the long-term survivors of high grade serous ovarian cancer?
Academic Article	Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis.
Academic Article	m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Academic Article	The road to long-term survival: Surgical approach and longitudinal treatments of long-term survivors of advanced-stage serous ovarian cancer.
Academic Article	Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
Academic Article	Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum.
Academic Article	SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.
Academic Article	Interpretation of Mismatch Repair Protein Immunohistochemistry in Endometrial Carcinoma Should Consider Both Lynch Syndrome Screening and Immunotherapy Susceptibility: An Illustrative Case Report.
Academic Article	Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis.
Academic Article	Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6.
Academic Article	New Roles for Glycogen in Tumor Progression.
Academic Article	Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake.
Academic Article	RADAR: differential analysis of MeRIP-seq data with a random effect model.
Academic Article	Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance.
Academic Article	Complete Response in a Patient With Chemorefractory EGFR-Amplified, PD-L1-Positive Metastatic Gastric Cancer Treated By Dual Anti-EGFR and Anti-PD-1 Monoclonal Antibody Therapy.
Academic Article	Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment.
Academic Article	Twenty-year longitudinal study on aged people in Budapest.
Academic Article	Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Academic Article	Germline mutations in Black patients with ovarian, fallopian tube and primary peritoneal carcinomas.
Academic Article	Neoadjuvant Chemotherapy Induces Genomic and Transcriptomic Changes in Ovarian Cancer.
Academic Article	High glucocorticoid receptor expression in the sarcomatous versus carcinomatous elements of Mullerian carcinosarcomas.
Academic Article	Molecular Characterizations of Gynecologic Carcinosarcomas: A Focus on the Immune Microenvironment.
Academic Article	A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencing.
Academic Article	Cancer-associated mesothelial cell-derived ANGPTL4 and STC1 promote the early steps of ovarian cancer metastasis.
Concept	MutL Protein Homolog 1
Concept	Protein Domains
Concept	Forkhead Box Protein L2
Concept	T-Lymphoma Invasion and Metastasis-inducing Protein 1
Concept	Clustered Regularly Interspaced Short Palindromic Repeats
Academic Article	The glycoprotein CD147 defines miRNA-enriched extracellular vesicles that derive from cancer cells.
Academic Article	Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis.
Academic Article	5-Hydroxymethylcytosine signals in serum are a predictor of chemoresistance in high-grade serous ovarian cancer.

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